Relafen Osteoarthritis also known as degenerative joint disease is the most frequent cause of joint pain.   This disease is one of the main causes of working capacity loss in men over 50 and is second to coronary heart disease in this respect. Osteoarthritis occurs due to interaction of mechanical and biological factors. This process starts as changes in cartilage or subchondral bone or as a result of a disease within these tissues (e.g. genetic defect, ochronosis), or is caused by an external anomalous mechanical stress (e.g. joint instability, injuries or heavy loads).  As the disease progresses the changes mentioned become more apparent.  There is evidence that professional risk of developing femoral osteoarthritis occurs due to heavy physical loads associated with job.  Pain, This diseases and constrained joint motion are the main manifestations of the diseases.  The cardinal symptom is the pain which first is felt in joints after motions but which get better at rest. Relafen (Nabumetone) has an anti-inflammatory, analgesic and antipyretic action.  The starting dose of Relafen (Nabumetone) is 1 g once a day independently of food intake. In some cases the dose could be increased to 1,5 – 2,0 g a day, 1 – 2 times a day.

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